benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

Base Information

Chemical Name:benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate
CAS No.:480460-68-2
Molecular Formula:C₂₂H₂₉NO₈
Molecular Weight:435.474
Hs Code.:

Synonyms:benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

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Chemical Property of benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

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Technology Process of benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

There total 3 articles about benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027237-79-1
2-tert-butoxycarbonylamino-4-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-4-oxo-butyric acid benzyl ester

: 480460-68-2
benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

Guidance literature:: With sodium tetrahydroborate; acetic acid; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo025950c

Reference yield:

: 2033-24-1
cycl-isopropylidene malonate

: 480460-68-2
benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; DMAP / CH₂Cl₂ / 3 h / 20 °C

2: 6.34 g / NaBH₄; AcOH / CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium tetrahydroborate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1021/jo025950c

Reference yield:

: 30925-18-9
2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 480460-68-2
benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxolan-5-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; DMAP / CH₂Cl₂ / 3 h / 20 °C

2: 6.34 g / NaBH₄; AcOH / CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium tetrahydroborate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1021/jo025950c