3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

Base Information

Chemical Name:3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)
CAS No.:1269818-18-9
Molecular Formula:C₃₉H₄₂N₂O₂
Molecular Weight:570.775
Hs Code.:

Synonyms:3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

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Chemical Property of 3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

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Technology Process of 3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

There total 6 articles about 3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1269818-15-6
1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole

: 100-52-7
benzaldehyde

: 1269818-18-9
3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/ja110427e

Reference yield:

: 1269818-11-2
2-tert-butyl 1-ethyl 3-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole-1,2-dicarboxylate

: 1269818-18-9
3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethylene glycol / 0.5 h / 195 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With trifluoroacetic acid; potassium hydroxide; In dichloromethane; ethylene glycol;
DOI:10.1021/ja110427e

Reference yield:

: 1269818-08-7
ethyl 3-bromo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

: 1269818-18-9
3,3'-(phenylmethylene)bis(1-(2-methoxy-5-methylphenyl)-4,5,6,7-tetrahydro-2H-isoindole)

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / acetonitrile / 16 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; water; toluene / 16 h / 80 °C / Inert atmosphere

3: potassium hydroxide / ethylene glycol / 0.5 h / 195 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; potassium hydroxide; In methanol; dichloromethane; water; ethylene glycol; toluene; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/ja110427e