C₂₆H₂₂ClNO₃

Base Information

• Chemical Name: C₂₆H₂₂ClNO₃
• CAS No.: 130031-65-1
• Molecular Formula: C₂₆H₂₂ClNO₃
• Molecular Weight: 431.919
• Mol file: 130031-65-1.mol

Synonyms:C₂₆H₂₂ClNO₃

Chemical Property of C₂₆H₂₂ClNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₂ClNO₃

There total 15 articles about C₂₆H₂₂ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C26H19NO3 (130031-64-0,141783-00-8) → C26H22ClNO3 (130031-65-1)

Guidance literature:

With hydrogenchloride; cyclohexa-1,4-diene; In dichloromethane; at 25 ℃; for 0.0166667h;

DOI:10.1021/ja00176a064

Reference yield: 79.0%

cyclohexa-1,4-diene (1165952-92-0) + C26H19NO3 (130031-64-0,141783-00-8) → C26H22ClNO3 (130031-65-1)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 25 ℃; for 0.0166667h;

DOI:10.1021/ja00008a045

Reference yield:

7,8,9,10-tetrahydrophenanthridine (62833-92-5) → C26H22ClNO3 (130031-65-1)

Guidance literature:

Multi-step reaction with 14 steps

1: 78 percent / mCPBA / CH₂Cl₂ / 1 h / 25 °C

2: 87 percent / 20 h / 100 °C

3: 100 percent / K₂CO₃ / methanol / 1 h / 25 °C

4: 92 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5: 1.) THF, -78 degC to 0 deg C, 2.) -78 deg C to 25 deg C, 1 h

6: 85 percent / mCPBA / CH₂Cl₂ / 2 h / 25 °C

7: 100 percent / Bu₄NF / tetrahydrofuran / 3 h / 42 °C

8: 80 percent / pyridinium chlorochromate, 4-Angstroem molecular sieves / CH₂Cl₂ / 1 h / 25 °C

9: 1.) Pd(CH₃COO)2, Ph₃P, n-BuNH₂, 2.) Cu₂I₂ / 1.) C₆H₆, 25 deg C, 15 min, 2.) 25 deg C, 2 h

10: 1.) AgNO₃, 2.) KCN / 1.) H₂O, C₂H₅OH, THF, 25 deg C, 5 min, 2.) 10 min

11: 59 percent / LDA / toluene; cyclohexane / 1 h / -78 °C

12: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 25 °C

13: 86 percent / n-Bu₃SnH, AlBN / toluene / 2 h / 80 °C

14: 79 percent / HCl / CH₂Cl₂ / 0.02 h / 25 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; potassium cyanide; palladium diacetate; copper (I) iodide; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; potassium carbonate; silver nitrate; N-butylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene;

DOI:10.1021/ja00008a045

upstream raw materials:

cyclohexa-1,4-diene

C₂₆H₁₉NO₃

7,8,9,10-tetrahydrophenanthridine

7,8,9,10-tetrahydrophenanthridine N-oxide