2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

Base Information

Chemical Name:2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde
CAS No.:1415010-38-6
Molecular Formula:C₂₆H₄₀N₂O₆SSi
Molecular Weight:536.765
Hs Code.:

Synonyms:2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

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Chemical Property of 2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

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Technology Process of 2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

There total 17 articles about 2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₄₂N₂O₆SSi

: 1415010-38-6
2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1021/ol302880x

Reference yield:

: 1415010-31-9
(3aS,5aS,9aS,9bR)-3a-allyl-6,6,9a-trimethyl-3-(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indole

: 1415010-38-6
2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetonitrile / 17 h / 20 °C / Inert atmosphere

2: sodium periodate / tetrahydrofuran; water / 2 h / 20 °C

With sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/ol302880x

Reference yield:

: 60134-39-6
(-)-(4aS,8aS)-3,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethylnaphthalen-1(2H)-one

: 1415010-38-6
2-(3aS,5aS,9aS,9bR)-6,6,9a-trimethyl-3-[(2-nitrobenzenesulfonyl)-9b-(trimethylsilyloxy)perhydro-1H-benzo[e]indol-3a-yl]acetaldehyde

Guidance literature:: Multi-step reaction with 17 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid; water / dichloromethane / 0.33 h / 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

5.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

5.2: 0.08 h / Inert atmosphere

6.1: tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

8.1: cyclohexane; borane-THF / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

8.2: 0.5 h / 20 °C / Inert atmosphere

9.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

10.1: hydrazine / chloroform / 0.33 h / 20 °C

11.1: acetic acid / ethanol / 12 h / Reflux

12.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

12.2: 0.08 h / 0 °C

13.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

14.1: pyridine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

14.2: 24 h / 20 °C / Inert atmosphere

15.1: triphenylphosphine; acetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triethylamine / tetrahydrofuran / 20.17 h / 20 °C / Inert atmosphere

16.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / water; acetonitrile / 17 h / 20 °C / Inert atmosphere

17.1: sodium periodate / tetrahydrofuran; water / 2 h / 20 °C

With pyridine; 2,6-dimethylpyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium periodate; osmium(VIII) oxide; borane-THF; cyclohexane; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; water; toluene; acetonitrile;
DOI:10.1021/ol302880x