(2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride

Base Information

• Chemical Name: (2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride
• CAS No.: 175671-43-9
• Molecular Formula: C₇H₁₃NO₃*ClH
• Molecular Weight: 195.646
• Hs Code.: 2933399990
• Mol file: 175671-43-9.mol

Synonyms:2-Piperidinecarboxylicacid, 4-hydroxy-, methyl ester, hydrochloride, (2S-cis)- (9CI)

Chemical Property of (2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.000193mmHg at 25°C
• Melting Point: 173-176℃
• Boiling Point: 292.6°C at 760 mmHg
• Flash Point: 130.8°C
• PSA: 58.56000
• LogP: 0.40310

Purity/Quality:

98%min ^*data from raw suppliers

(2S,4R)-methyl4-hydroxypiperidine-2-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride

There total 1 articles about (2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 4(R)-hydroxypiperidine-2(R)-carboxylate (189952-45-2) → (2S,4R)-methyl 4-hydroxypiperidine-2- carboxylate hydrochloride (1104460-09-4,175671-43-9,337464-25-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; acetone; pH=3 - 4;

DOI:10.1016/j.bmcl.2008.08.083

Reference yield:

(2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride (175671-43-9,337464-25-2) → (2S,4R)-4-hydroxypiperidine-2-carboxylic acid (1844-40-2,175671-49-5,189385-64-6)

Guidance literature:

With hydrogenchloride; Yield given; Heating;

DOI:10.1021/jo9519874

upstream raw materials:

methyl 4(R)-hydroxypiperidine-2(R)-carboxylate

Downstream raw materials:

(2S,4R)-4-hydroxypiperidine-2-carboxylic acid

Refernces