2-Piperidinecarboxylicacid,4-hydroxy-,methylester,trans-(9CI)

Base Information

• Chemical Name: 2-Piperidinecarboxylicacid,4-hydroxy-,methylester,trans-(9CI)
• CAS No.: 189952-45-2
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.185
• Mol file: 189952-45-2.mol

Synonyms:2-Piperidinecarboxylicacid, 4-hydroxy-, methyl ester, trans- (9CI)

Chemical Property of 2-Piperidinecarboxylicacid,4-hydroxy-,methylester,trans-(9CI)

Chemical Property:

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Technology Process of 2-Piperidinecarboxylicacid,4-hydroxy-,methylester,trans-(9CI)

There total 26 articles about 2-Piperidinecarboxylicacid,4-hydroxy-,methylester,trans-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 1-benzyl-4-hydroxypiperidine-2-carboxylic acid → 4-hydroxy-2-piperidine carboxylic acid methyl ester (144913-66-6,189952-45-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; for 24h; under 2585.81 Torr;

Reference yield: 100.0%

methanol (67-56-1) + (1α,5α)-2-(phenylmethyl)-6-oxa-2-azabicyclo<3.2.1>octan-7-one (133192-43-5) → methyl cis-4-hydroxy-2-piperidinecarboxylate (133192-44-6,189952-45-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 2.2h; under 2606.4 Torr;

DOI:10.1021/jo00012a061

Reference yield: 100.0%

(2S,4R)-1-benzyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate (403503-37-7,1357348-22-1) → methyl 4(R)-hydroxypiperidine-2(S)-carboxylate (211058-80-9,189952-45-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2015.09.009

upstream raw materials:

methanol

(1α,5α)-2-(phenylmethyl)-6-oxa-2-azabicyclo<3.2.1>octan-7-one

C₁₄H₁₇NO₂

2-oxo-propionic acid

Downstream raw materials:

(2S,4R)-4-Hydroxy-piperidine-1,2-dicarboxylic acid 1-benzyl ester

N-Boc-4-hydroxy-2-piperidine carboxylic acid methyl ester

(2R,4S)-4-hydroxypipecolic acid methyl ester

(2R,4S) (+)-cis-4-hydroxy-2-pipecolic acid

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