1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate

Base Information

• Chemical Name: 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate
• CAS No.: 913963-45-8
• Molecular Formula: C₂₅H₃₇N₂O₂P
• Molecular Weight: 428.555
• Mol file: 913963-45-8.mol

Synonyms:1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate

Chemical Property of 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate

There total 4 articles about 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate (123387-72-4) + (2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0) → 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate (913963-45-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

DOI:10.1002/hlca.200690157

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate (913963-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 55 percent / DMAP / tetrahydrofuran / 19 h / 20 °C

2: 11.56 g / KH / dimethylformamide / 3.5 h / 0 - 25 °C

3: 6.38 g / O₃ / methanol; CH₂Cl₂ / 0.5 h / -78 °C

4: 74 percent / NaHB(OAc)3 / 1,2-dichloro-ethane / 4 h / 20 °C

With dmap; potassium hydride; sodium tris(acetoxy)borohydride; ozone; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200690157

Reference yield:

N-(tert-butoxycarbonyl)methylamine (16066-84-5) → 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}methylcarbamate (913963-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 11.56 g / KH / dimethylformamide / 3.5 h / 0 - 25 °C

2: 6.38 g / O₃ / methanol; CH₂Cl₂ / 0.5 h / -78 °C

3: 74 percent / NaHB(OAc)3 / 1,2-dichloro-ethane / 4 h / 20 °C

With potassium hydride; sodium tris(acetoxy)borohydride; ozone; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200690157

upstream raw materials:

O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate

(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine

di-tert-butyl dicarbonate

N-(tert-butoxycarbonyl)methylamine

Downstream raw materials:

N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N'-methyl-ethane-1,2-diamine