(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Name:(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester
CAS No.:143817-70-3
Molecular Formula:C₄₁H₅₈N₂O₈Si
Molecular Weight:735.006
Hs Code.:

(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Synonyms:(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Property of (S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Technology Process of (S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

There total 20 articles about (S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 143817-70-3
(R)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / LiAlH₄ / diethyl ether

2: 87 percent / p-toluenesulfonic acid / acetone

3: 82 percent / DCC, DMAP

4: 64 percent / Tebbe's reagent / toluene

5: toluene / 120 °C

6: DDQ

7: methanol, p-toluenesulfonic acid / Ambient temperature

8: Et₃N, DMAP / CH₂Cl₂

9: NaBH₄ / methanol

10: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

With methanol; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jo00048a005

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 143817-70-3
(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / LiAlH₄ / diethyl ether

2: 87 percent / p-toluenesulfonic acid / acetone

3: 82 percent / DCC, DMAP

4: 64 percent / Tebbe's reagent / toluene

5: 46 percent / toluene / 120 °C

6: DDQ

7: 68 percent / methanol, p-toluenesulfonic acid / Ambient temperature

8: 100 percent / Et₃N, DMAP / CH₂Cl₂

9: 93 percent / NaBH₄ / methanol

10: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

With methanol; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane; acetone; toluene;
DOI:10.1021/jo00048a005

Reference yield:

: 83345-46-4,282100-80-5
N-(tert-butyloxycarbonyl)-L-tyrosinol

: 143817-70-3
(S)-4-(3-{4-[(S)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-phenoxy}-4-methoxy-benzyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / p-toluenesulfonic acid / acetone

2: 82 percent / DCC, DMAP

3: 64 percent / Tebbe's reagent / toluene

4: 46 percent / toluene / 120 °C

5: DDQ

6: 68 percent / methanol, p-toluenesulfonic acid / Ambient temperature

7: 100 percent / Et₃N, DMAP / CH₂Cl₂

8: 93 percent / NaBH₄ / methanol

9: 1.) thiocarbonyl diimidazole, DMAP, 2.) n-Bu₃SnH, AIBN / 2.) toluene

With methanol; dmap; sodium tetrahydroborate; Tebbe's reagent; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; di(1H-imidazol-2-yl)methanethione; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; acetone; toluene;
DOI:10.1021/jo00048a005