[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

Base Information

Chemical Name:[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester
CAS No.:1310350-66-3
Molecular Formula:C₂₁H₂₆F₃N₃O₇
Molecular Weight:489.449
Hs Code.:

Synonyms:[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

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Chemical Property of [(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

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Technology Process of [(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

There total 6 articles about [(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 1310350-22-1
(R)-5,5-difluoro-4-(2-fluoro-5-nitrophenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

: 1310350-66-3
[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1075231-03-6
(R)-2-methylpropane-2-sulfinic acid [(R)-2,2-difluoro-1-(2-fluoro-5-nitrophenyl)-3-hydroxy-1-methylpropyl]amide

: 1310350-66-3
[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 23 °C

2: ethanol / 24 h / 85 °C / Inert atmosphere; Sealed tube

3: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; dmap; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1310350-66-3
[(R)-5,5-difluoro-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-dicarbamic acid bis-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2: zinc / diethyl ether / 5.25 h / 34 - 35 °C / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 23 °C

5: ethanol / 24 h / 85 °C / Inert atmosphere; Sealed tube

6: dmap; triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; dmap; lithium borohydride; triethylamine; zinc; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol;