(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

Base Information

Chemical Name:(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester
CAS No.:1075231-02-5
Molecular Formula:C₁₆H₂₁F₃N₂O₅S
Molecular Weight:410.414
Hs Code.:

Synonyms:(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

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Chemical Property of (R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

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Technology Process of (R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

There total 4 articles about (R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 1075230-62-4
(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

: 1075231-02-5
(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

Guidance literature:: Ethyl bromodifluoroacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 22 - 35 ℃; for 0.5h; Inert atmosphere;

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide; In tetrahydrofuran; at 22 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400225m

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 1076160-56-9
(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1075231-02-5
(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

Guidance literature:: Ethyl bromodifluoroacetate; With zinc; In tetrahydrofuran; at 20 ℃; for 0.75h; Inert atmosphere;

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; for 8h; Inert atmosphere;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1075231-02-5
(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2: zinc / diethyl ether / 5.25 h / 34 - 35 °C / Inert atmosphere

With zinc; titanium(IV) tetraethanolate; In tetrahydrofuran; diethyl ether;