tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Name:tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
CAS No.:1400286-84-1
Molecular Formula:C₂₇H₃₁N₅O₅
Molecular Weight:505.574
Hs Code.:

Synonyms:tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Property of tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Technology Process of tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

There total 11 articles about tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1400286-62-5
tert-butyl 6-bromo-2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 104-94-9
4-methoxy-aniline

: 1400286-84-1
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1-methyl-pyrrolidin-2-one; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1300750-78-0
4-amino-2-bromo-5-iodopyridine

: 1400286-84-1
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1.73 h / 20 °C / Cooling with ice

2: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

3: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.17 h / 60 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; methanol / 3 h / 40 °C

5: triethylamine / dmap / ethyl acetate / 3 h / 20 °C

6: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one; water / 2 h / 80 °C / Inert atmosphere

With potassium phosphate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1400286-59-0
N-(2-bromo-5-iodopyridin-4-yl)-N-(methylsulfonyl)methanesulfonamide

: 1400286-84-1
tert-butyl 2-(1-(tert-butoxycarbonyl)-1H-pyrazol-4-yl)-6-(4-methoxyphenylamino)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.17 h / 60 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; methanol / 3 h / 40 °C

4: triethylamine / dmap / ethyl acetate / 3 h / 20 °C

5: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one; water / 2 h / 80 °C / Inert atmosphere

With potassium phosphate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; dmap; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; ethyl acetate; N,N-dimethyl-formamide;