4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one

Base Information

• Chemical Name: 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one
• CAS No.: 118485-77-1
• Molecular Formula: C₂₃H₂₉N₅O₂
• Molecular Weight: 407.516

Synonyms:4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one

Chemical Property of 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one

Chemical Property:

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Technology Process of 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one

There total 4 articles about 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one (1339803-76-7) → 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one (118485-77-1)

Guidance literature:

With water; hydrogen bromide; at 110 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm200944b

Reference yield:

1-Bromopentane (110-53-2) → 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one (118485-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: water; hydrogen bromide / 6 h / 110 °C / Inert atmosphere

With water; hydrogen bromide; potassium carbonate; In dimethyl sulfoxide;

DOI:10.1021/jm200944b

Reference yield:

2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one (74853-07-9) → 4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one (118485-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: water; hydrogen bromide / 6 h / 110 °C / Inert atmosphere

With water; hydrogen bromide; potassium carbonate; In dimethyl sulfoxide;

DOI:10.1021/jm200944b

upstream raw materials:

4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1-pentyl-1H-1,2,4-triazol-5(4H)-one

1-Bromopentane

2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one

Downstream raw materials:

cis-(2S,4R)-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-pentyl-3H-1,2,4-triazol-3-one

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