C₆₅H₉₃FO₁₀SSi₂

Base Information

Chemical Name:C₆₅H₉₃FO₁₀SSi₂
CAS No.:1373634-27-5
Molecular Formula:C₆₅H₉₃FO₁₀SSi₂
Molecular Weight:1141.68
Hs Code.:

C<sub>65</sub>H<sub>93</sub>FO<sub>10</sub>SSi<sub>2</sub>

Synonyms:C₆₅H₉₃FO₁₀SSi₂

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Chemical Property of C₆₅H₉₃FO₁₀SSi₂

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Technology Process of C₆₅H₉₃FO₁₀SSi₂

There total 14 articles about C₆₅H₉₃FO₁₀SSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1373634-83-3
C₅₃H₆₅FO₁₀S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1373634-27-5
C₆₅H₉₃FO₁₀SSi₂

Guidance literature:: With pyridine; silver nitrate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol300672q

Reference yield:

: 1191256-12-8
C₂₅H₂₆O₇

: 1373634-27-5
C₆₅H₉₃FO₁₀SSi₂

Guidance literature:: Multi-step reaction with 13 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / 0 - 20 °C / Inert atmosphere

1.2: 0.67 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 0.17 h / 0 °C / Inert atmosphere

5.1: Crabtree's catalyst; hydrogen / dichloromethane / 0 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: chromium dichloride; manganese; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 4 h / 20 °C / Inert atmosphere

8.1: triethylsilane; triethylsilyl trifluoromethyl sulfonate / acetonitrile / 0.33 h / -40 °C / Inert atmosphere

9.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

10.1: chromium dichloride; manganese; zirconocene dichloride; C₂₆H₃₂Cl₂N₂O₄S; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 3 h / 20 °C / Inert atmosphere

11.1: 18-crown-6 ether; potassium hydride / toluene / 24 h / 0 - 20 °C / Inert atmosphere

12.1: diisobutylaluminium hydride / toluene / 3 h / -78 °C / Inert atmosphere

13.1: pyridine; silver nitrate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With pyridine; chromium dichloride; triethylsilane; manganese; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; zirconocene dichloride; Crabtree's catalyst; 18-crown-6 ether; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₂₆H₃₂Cl₂N₂O₄S; water; hydrogen; triethylsilyl trifluoromethyl sulfonate; potassium hydride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; silver nitrate; 4-methylmorpholine N-oxide; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol300672q

Reference yield:

: 1373634-51-5
C₃₂H₃₁FO₈S

: 1373634-27-5
C₆₅H₉₃FO₁₀SSi₂

Guidance literature:: Multi-step reaction with 12 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 0.17 h / 0 °C / Inert atmosphere

4: Crabtree's catalyst; hydrogen / dichloromethane / 0 °C / Inert atmosphere

5: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: chromium dichloride; manganese; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 4 h / 20 °C / Inert atmosphere

7: triethylsilane; triethylsilyl trifluoromethyl sulfonate / acetonitrile / 0.33 h / -40 °C / Inert atmosphere

8: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

9: chromium dichloride; manganese; zirconocene dichloride; C₂₆H₃₂Cl₂N₂O₄S; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 3 h / 20 °C / Inert atmosphere

10: 18-crown-6 ether; potassium hydride / toluene / 24 h / 0 - 20 °C / Inert atmosphere

11: diisobutylaluminium hydride / toluene / 3 h / -78 °C / Inert atmosphere

12: pyridine; silver nitrate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With pyridine; chromium dichloride; triethylsilane; manganese; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; zirconocene dichloride; Crabtree's catalyst; 18-crown-6 ether; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₂₆H₃₂Cl₂N₂O₄S; water; hydrogen; triethylsilyl trifluoromethyl sulfonate; potassium hydride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; silver nitrate; 4-methylmorpholine N-oxide; lithium chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol300672q