C₄₃H₅₂O₈

Base Information

• Chemical Name: C₄₃H₅₂O₈
• CAS No.: 403704-42-7
• Molecular Formula: C₄₃H₅₂O₈
• Molecular Weight: 696.881
• Mol file: 403704-42-7.mol

Synonyms:C₄₃H₅₂O₈

Chemical Property of C₄₃H₅₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₅₂O₈

There total 12 articles about C₄₃H₅₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C43H54O8 (404574-51-2) → C43H52O8 (403704-50-7) + C43H52O8 (403704-42-7)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; at 0 ℃; for 8h;

DOI:10.1021/ol0165894

Reference yield:

Benzoic acid (2S,4aS,4bS,6S,6aR,6bR,7S,8R,9aS,10bR,12aS)-2-acetoxy-4a,6a,7-trimethyl-8-(3-methyl-but-3-enyl)-2,3,4,4a,4b,5,6,6a,6b,7,8,9a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-6-yl ester (403704-37-0) → C43H52O8 (403704-42-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / OsO₄; K₃Fe(CN)6; K₂CO₃ / (DHQ)2PYR / 2-methyl-propan-2-ol; H₂O / 28 h / 0 °C

2: 97 percent / imidazole; DMAP / dimethylformamide / 1.5 h / 25 °C

3: 87 percent / MgBr₂*OEt₂; triethylamine / CH₂Cl₂ / 18 h / 25 °C

4: 96 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.08 h / 0 °C

5: 77 percent / PhI(OAc)2; iodine / 8 h / 0 °C

With 1H-imidazole; dmap; osmium(VIII) oxide; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; iodine; potassium carbonate; triethylamine; magnesium bromide; potassium hexacyanoferrate(III); (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation / 5: Suarez iodine(III) oxidative spirocyclization;

DOI:10.1021/ol0165894

Reference yield:

benzoyl chloride (98-88-4) → C43H52O8 (403704-42-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 79 percent / 4-(dimethylamino)pyridine; pyridine / 5 h / 25 °C

2: 94 percent / BF₃*OEt₂; triethylsilane / CH₂Cl₂ / 7 h / 0 - 20 °C

3: triphenylphosphine; iodine; imidazole / diethyl ether; acetonitrile / 2 h / 0 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 2 h / 80 °C

5: 98 percent / OsO₄; K₃Fe(CN)6; K₂CO₃ / (DHQ)2PYR / 2-methyl-propan-2-ol; H₂O / 28 h / 0 °C

6: 97 percent / imidazole; DMAP / dimethylformamide / 1.5 h / 25 °C

7: 87 percent / MgBr₂*OEt₂; triethylamine / CH₂Cl₂ / 18 h / 25 °C

8: 96 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.08 h / 0 °C

9: 77 percent / PhI(OAc)2; iodine / 8 h / 0 °C

With pyridine; 1H-imidazole; triethylsilane; dmap; osmium(VIII) oxide; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; iodine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; magnesium bromide; potassium hexacyanoferrate(III); (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 5: Sharpless asymmetric dihydroxylation / 9: Suarez iodine(III) oxidative spirocyclization;

DOI:10.1021/ol0165894

upstream raw materials:

C₄₃H₅₄O₈

benzoyl chloride

3β-acetoxy-12α-hydroxy-5α-spirostan-14-ene

(25R)-3β-Acetoxy-12,13-seco-5α-spirost-13-en-12-on

Downstream raw materials:

C₄₁H₄₇N₃O₇

C₄₁H₄₇BrO₇

C₄₁H₄₈O₇

C₄₁H₅₀O₇