(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

Base Information

Chemical Name:(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate
CAS No.:912959-43-4
Molecular Formula:C₁₆H₁₉NO₆S
Molecular Weight:353.396
Hs Code.:

Synonyms:(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

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Chemical Property of (+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

Chemical Property:

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Technology Process of (+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

There total 6 articles about (+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 912959-42-3
(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one

: 124-63-0
methanesulfonyl chloride

: 912959-43-4
(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

Guidance literature:: With triethylamine; In diethyl ether; dichloromethane; at 0 ℃; for 2h;
DOI:10.1071/CH05181

Reference yield:

: 912959-36-5
(+/-)-4-[3-{[(1,1-dimethylethyl)dimethylsilyl]oxy}propyl]-2-cyclohexen-1-one

: 912959-43-4
(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine; iodine / CCl₄ / 16 h / 18 °C

2: 69 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 16 h / 70 °C

3: 100 percent / HCl / ethanol; H₂O / 3 h / 0 - 18 °C

4: 72 percent / triethylamine / diethyl ether; CH₂Cl₂ / 2 h / 0 °C

With pyridine; hydrogenchloride; iodine; copper; triethylamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1071/CH05181

Reference yield:

: 871927-34-3
(+/-)-6-{3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl}-3-ethoxy-2-cyclohexen-1-one

: 912959-43-4
(+/-)-4-(3-hydroxypropyl)-2-(2-nitrophenyl)-2-cyclohexen-1-one methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 18 °C

2: 82 percent / pyridine; iodine / CCl₄ / 16 h / 18 °C

3: 69 percent / copper / Pd₂(dba)3 / dimethylsulfoxide / 16 h / 70 °C

4: 100 percent / HCl / ethanol; H₂O / 3 h / 0 - 18 °C

5: 72 percent / triethylamine / diethyl ether; CH₂Cl₂ / 2 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; iodine; copper; triethylamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1071/CH05181