(S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane

Base Information

• Chemical Name: (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane
• CAS No.: 330835-00-2
• Molecular Formula: C₂₈H₃₆O₂Si
• Molecular Weight: 432.678
• Mol file: 330835-00-2.mol

Synonyms:(S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane

Chemical Property of (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane

There total 2 articles about (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-1,3-pentanediol 1-benzyl ether (95338-12-8) + tert-butylchlorodiphenylsilane (58479-61-1) → (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane (330835-00-2)

Guidance literature:

With 1H-imidazole; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/ol0069047

Reference yield:

(2R)-2-(2-benzyloxyethyl)oxirane (115114-87-9) → (S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane (330835-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.17 h / -40 °C

1.2: 96 percent / tetrahydrofuran / 1 h / -40 °C

2.1: 94 percent / imidazole / acetonitrile / 24 h / 20 °C

With 1H-imidazole; copper(l) iodide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ol0069047

Reference yield:

(S)-(3-benzyloxy-1-ethylpropoxy)-tert-butyl-diphenyl-silane (330835-00-2) → (3S)-3-(tert-butyl-diphenyl-silanyloxy)pentan-1-ol (330835-04-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 5h; under 1551.49 Torr;

DOI:10.1021/ol0069047

upstream raw materials:

(S)-1,3-pentanediol 1-benzyl ether

tert-butylchlorodiphenylsilane

(2R)-2-(2-benzyloxyethyl)oxirane

Downstream raw materials:

(3S)-3-(tert-butyl-diphenyl-silanyloxy)pentan-1-ol

(1S)-tert-butyl-(1-ethyl-3-iodopropoxy)-diphenyl-silane

2-[(4'S)-4'-(tert-butyl-diphenyl-silanyloxy)-hexyl]-tetrahydropyran-2-ol

(9S)-9-(tert-butyl-diphenyl-silanyloxy)-1-(tetrahydropyran-2-yloxy)-undeca-5-one