2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylic acid

Base Information

• Chemical Name: 2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylic acid
• CAS No.: 175401-95-3
• Molecular Formula: C15H9 N3 O2
• Molecular Weight: 263.255
• Mol file: 175401-95-3.mol

Synonyms:1H-Benzimidazole-5-carboxylicacid, 2-(4-cyanophenyl)- (9CI); 2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylicacid

Chemical Property of 2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylic acid

Chemical Property:

• PSA: 89.77000
• LogP: 2.79978

Purity/Quality:

2-(4-Cyanophenyl)-1H-benzo[d]imidazole-6-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylic acid

There total 4 articles about 2-(4-Cyanophenyl)-1H-benzimidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-(4-cyanophenyl)-4-azabenzimidazole-5-carboxylate → 2-(4-cyanophenyl)benzimidazole-5-carboxylic acid (175401-95-3)

Guidance literature:

With dimethyl sulfoxide; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.6b02359

Reference yield: 90.0%

4-cyanobenzaldehyde (105-07-7) + 3,4-diaminobenzoic acid (619-05-6) → 2-(4-cyanophenyl)benzimidazole-5-carboxylic acid (175401-95-3)

Guidance literature:

With MCM-41-SO₃H mesoporous nanoparticles; In water; at 20 ℃; for 0.583333h; chemoselective reaction;

DOI:10.1515/hc-2011-0056

Reference yield: 30.0%

4-cyanobenzoyl chlorIde (6068-72-0) + 3,4-diaminobenzoic acid (619-05-6) → 2-(4-cyanophenyl)benzimidazole-5-carboxylic acid (175401-95-3)

Guidance literature:

With acetic acid; Heating;

DOI:10.1016/0960-894X(95)00590-P

upstream raw materials:

4-cyanobenzoyl chlorIde

3,4-diaminobenzoic acid

4-cyanobenzaldehyde

Downstream raw materials:

3-{[2-(4-Cyano-phenyl)-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid methyl ester

(S)-3-{[2-(4-Aminomethyl-phenyl)-1H-benzoimidazole-5-carbonyl]-amino}-N-[2-(1H-indol-3-yl)-ethyl]-succinamic acid methyl ester

(S)-2-Butoxycarbonylamino-3-{[2-(4-carbamimidoyl-phenyl)-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid methyl ester

(S)-3-{[2-(4-Aminomethyl-phenyl)-1H-benzoimidazole-5-carbonyl]-amino}-N-phenethyl-succinamic acid methyl ester

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