2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

Base Information

Chemical Name:2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol
CAS No.:202460-03-5
Molecular Formula:C₃₆H₄₉N₃O₈SSi
Molecular Weight:711.952
Hs Code.:

Synonyms:2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

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Chemical Property of 2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

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Technology Process of 2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

There total 5 articles about 2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 124-63-0
methanesulfonyl chloride

: 202460-02-4
2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

: 202460-03-5
2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1246/bcsj.71.259

Reference yield:

: 96-22-0
pentan-3-one

: 202460-03-5
2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

Guidance literature:: Multi-step reaction with 3 steps

1: 3.48 g / p-toluenesulfonic acid monohydrate / 5 h / 20 °C

2: 100 percent / imidazole / dimethylformamide / 10.2 h / 0 - 20 °C

3: 100 percent / triethylamine / CH₂Cl₂ / 1.17 h / 0 - 20 °C

With 1H-imidazole; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Cyclization / 2: silylation / 3: mesylation;
DOI:10.1246/bcsj.71.259

Reference yield:

: (2S,3S,4S,5S)-5-Azido-4-(4-methoxy-benzyloxy)-hexane-1,2,3,6-tetraol

: 202460-03-5
2-azido-1-O-(t-butyldiphenylsilyl)-2-deoxy-4-O-methanesulfonyl-3-O-(4-methoxybenzyl)-5,6-O-(1-ethylpropylidene)-L-mannitol

Guidance literature:: Multi-step reaction with 3 steps

1: 3.48 g / p-toluenesulfonic acid monohydrate / 5 h / 20 °C

2: 100 percent / imidazole / dimethylformamide / 10.2 h / 0 - 20 °C

3: 100 percent / triethylamine / CH₂Cl₂ / 1.17 h / 0 - 20 °C

With 1H-imidazole; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Cyclization / 2: silylation / 3: mesylation;
DOI:10.1246/bcsj.71.259