[3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester
• CAS No.: 915035-99-3
• Molecular Formula: C₃₇H₅₂N₂O₁₀P₂
• Molecular Weight: 746.775
• Mol file: 915035-99-3.mol

Synonyms:[3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

Chemical Property of [3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

There total 1 articles about [3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

tetraethyl 3-aminopropylidene-1,1-bisphosphonate (141473-49-6) + 3-(3,4-bis(benzyloxy)phenethylcarbamoyl) propanoic acid (300362-70-3) → [3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester (915035-99-3)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;

DOI:10.1021/ja0651355

Reference yield: 100.0%

[3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester (915035-99-3) → (1-(diethoxy-phosphoryl)-3-{3-[2-(3,4-dihydroxy-phenyl)-ethylcarbamoyl]-propionylamino}-propyl)-phosphonic acid diethyl ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 18h;

DOI:10.1021/ja0651355

Reference yield:

[3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester (915035-99-3) → (3-{3-[2-(3,4-dihydroxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-phosphono-propyl)-phosphonic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol / 18 h / 20 °C

2: 454 mg / bromotrimethylsilane / CHCl₃ / 24 h

With trimethylsilyl bromide; hydrogen; palladium on activated charcoal; In methanol; chloroform;

DOI:10.1021/ja0651355

upstream raw materials:

tetraethyl 3-aminopropylidene-1,1-bisphosphonate

3-(3,4-bis(benzyloxy)phenethylcarbamoyl) propanoic acid