TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE

Base Information

• Chemical Name: TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE
• CAS No.: 141473-49-6
• Molecular Formula: C11H27 N O6 P2
• Molecular Weight: 331.28
• Hs Code.: 2922499990
• Mol file: 141473-49-6.mol

Synonyms:Phosphonicacid, (3-aminopropylidene)bis-, tetraethyl ester (9CI); Tetraethyl 3-aminopropylidene-1,1-bisphosphonate

Chemical Property of TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE

Chemical Property:

• PSA: 116.70000
• LogP: 3.89380

Purity/Quality:

98%min ^*data from raw suppliers

TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE

There total 8 articles about TETRAETHYL(3-AMINOPROPYLIDENE)BISPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

tetraethyl 3-nitropropylidene-1,1-bisphosphonate (136496-87-2) → tetraethyl 3-aminopropylidene-1,1-bisphosphonate (141473-49-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; for 6h; Ambient temperature;

DOI:10.1080/10426509608046357

Reference yield:

1,1-bis(diethylphosphono)ethylene (37465-31-9) → tetraethyl 3-aminopropylidene-1,1-bisphosphonate (141473-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / NaH / tetrahydrofuran / 72 h / 20 °C

2: 62 percent / hydrogen / 10 percent Pd/C / ethanol / 24 h / 70 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1002/ejic.200600615

Reference yield:

Tetraethyl methylenediphosphonate (1660-94-2) → tetraethyl 3-aminopropylidene-1,1-bisphosphonate (141473-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethylamine / methanol / Heating

1.2: 94 percent / p-toluenesulfonic acid monohydrate / toluene / Heating

2.1: 83 percent / NaH / tetrahydrofuran / 72 h / 20 °C

3.1: 62 percent / hydrogen / 10 percent Pd/C / ethanol / 24 h / 70 °C

With hydrogen; sodium hydride; diethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;

DOI:10.1002/ejic.200600615

upstream raw materials:

tetraethyl 3-nitropropylidene-1,1-bisphosphonate

tetraethyl 3-azido-propane-1,1-bisphosphonate

Tetraethyl methylenediphosphonate

1,1-bis(diethylphosphono)ethylene

Downstream raw materials:

[1-phosphono-3-[4-[[2-(tritylthio)ethyl][[2-(tritylthio)ethylcarbamoyl]methyl]amino]butyrylamino]propyl]phosphonic acid tetraethyl ester

[3-{3-[2-(3,4-bis-benzyloxy-phenyl)-ethylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

tetraethyl (3R,5R)-3-N-(7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoyl)aminopropane-1,1-bisphosphonate

C₄₁H₅₃N₃O₉P₂