4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Base Information

Chemical Name:4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine
CAS No.:909867-57-8
Molecular Formula:C₁₉H₂₅Cl₂NOSi
Molecular Weight:382.405
Hs Code.:

4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Synonyms:4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Chemical Property:

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Technology Process of 4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

There total 3 articles about 4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 909867-56-7
3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 909867-57-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1246/cl.2006.712

Reference yield:

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 909867-57-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

1.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 71 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1246/cl.2006.712

Reference yield:

: 190906-91-3
3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

: 909867-57-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 0 °C

1.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 71 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1246/cl.2006.712