(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Base Information

Chemical Name:(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide
CAS No.:897025-07-9
Molecular Formula:C₂₅H₂₃ClN₆O₂
Molecular Weight:474.95
Hs Code.:

Synonyms:(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Suppliers and Price of (2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

There total 6 articles about (2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 897025-07-9
(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Guidance literature:

Reference yield:

: 897383-73-2
C₃₀H₃₁ClN₆O₄

: 897025-07-9
(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm901146p

Reference yield:

: 616-79-5
2-amino-5-nitro-benzoic acid

: 897025-07-9
(2S)-pyrrolidine-2-carboxylic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-quinazolin-6-yl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 170 °C

2: thionyl chloride; trichlorophosphate; N,N-dimethyl-formamide

3: isopropyl alcohol / Reflux

4: iron; hydrogenchloride / ethanol; water / Reflux

5: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridine / 20 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; iron; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N,N-dimethyl-formamide; trifluoroacetic acid; trichlorophosphate; In ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1002/bkcs.10358