3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Base Information

Chemical Name:3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate
CAS No.:114123-84-1
Molecular Formula:C₃₂H₄₅N₃O₉Si
Molecular Weight:643.809
Hs Code.:

Synonyms:3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Suppliers and Price of 3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

There total 9 articles about 3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 114091-07-5
(3-azido-5-methoxyphenoxy)acetic acid

: 114091-15-5
3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate

: 114123-84-1
3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Guidance literature:: With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 72h;
DOI:10.1016/S0040-4020(01)86831-9

Reference yield:

: 108-73-6
3,5-dihydroxyphenol

: 114123-84-1
3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: NH₃, HCl

2: 1.) cc. HCl, NaNO₂; 2.) NaN₃ / 1.) H₂O, 0 deg C, 10 min; 2.) H₂O, 0 deg C, 40 min

3: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) DMF, 25 deg C, 1 h

4: 90 percent / K₂CO₃ / 1,2-dimethoxy-ethane / 2 h / 80 °C

5: 92 percent / aq. KOH / aq. ethanol / 1 h / 25 °C

6: 89 percent / DCC, 4-(pyrrolidino)pyridine / CH₂Cl₂ / 72 h / 25 °C

With hydrogenchloride; potassium hydroxide; sodium azide; ammonia; sodium hydride; potassium carbonate; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; sodium nitrite; In 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)86831-9

Reference yield:

: 2270-40-8,28776-47-8
4,15-diacetoxyscirpenol

: 114123-84-1
3α-tert-butyldimethylsilyloxy-12,13-epoxytrichothec-9-ene-4β,15-diol 15-acetate 4β-(3-azido-5-methoxyphenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 18 h / 25 °C

2: 53 percent / NaOAc, NaOH / methanol; H₂O / 5 h / 25 °C

3: 89 percent / DCC, 4-(pyrrolidino)pyridine / CH₂Cl₂ / 72 h / 25 °C

With 1H-imidazole; sodium hydroxide; sodium acetate; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86831-9