(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

Base Information

Chemical Name:(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate
CAS No.:154811-81-1
Molecular Formula:C₃₄H₂₈O₇
Molecular Weight:548.592
Hs Code.:

Synonyms:(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

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Chemical Property of (2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

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Technology Process of (2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

There total 1 articles about (2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 90146-19-3
(2R)-methyl 1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-6,11-dioxonaphthacene-2-carboxylate

: 154811-81-1
(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; for 5h; Heating;
DOI:10.1016/S0040-4020(01)80235-0

Reference yield: 77.0%

: 154811-81-1
(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

: 154811-82-2
(2R)-5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; for 1h;
DOI:10.1016/S0040-4020(01)80235-0

Reference yield:

: 154811-81-1
(2R)-methyl 5,12-bis(phenylmethoxy)-1,2,3,4,6,11-hexahydro-2-hydroxy-6,11-dioxonaphthacene-2-carboxylate

: 154811-83-3
(8R)-6,11-bis(phenylmethoxy)-7,8,9,10-tetrahydro-8-hydroxy-8-hydroxymethyl-5,12-naphthacenedione

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / 3 percent KOH / tetrahydrofuran; methanol / 1 h

2: 51 percent / diborane / tetrahydrofuran / 4 h / Ambient temperature

With potassium hydroxide; diborane; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)80235-0