3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Base Information

Chemical Name:3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine
CAS No.:1608109-23-4
Molecular Formula:C₃₇H₄₄F₃N₃O₆SSi
Molecular Weight:743.92
Hs Code.:

Synonyms:3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

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Chemical Property of 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

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Technology Process of 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

There total 4 articles about 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1608109-22-3
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxy-2'-trifluoromethylthiouridine

: 1608109-23-4
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxy-2'-trifluoromethylthiouridine; With ammonia; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

Inert atmosphere;
DOI:10.1021/ja5005637

Reference yield:

: 1608109-21-2
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiouridine

: 1608109-23-4
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: ammonia / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With dmap; ammonia; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja5005637

Reference yield:

: 1421694-67-8
C₃₁H₂₉F₃N₂O₇S

: 1608109-23-4
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: ammonia / tetrahydrofuran; water / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With 1H-imidazole; dmap; ammonia; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja5005637