{(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Base Information

• Chemical Name: {(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate
• CAS No.: 944052-65-7
• Molecular Formula: C₂₄H₂₁NO₃
• Molecular Weight: 371.436
• Mol file: 944052-65-7.mol

Synonyms:{(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Chemical Property of {(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of {(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate

There total 1 articles about {(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(3S)-3-[(2R)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one (944052-62-4) + benzoic acid (65-85-0,8013-63-6) → {(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate (944052-65-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

DOI:10.1002/jhet.5570440312

Reference yield: 67.0%

{(1S)-2-[(1S)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1-(4-methylphenyl)ethyl} benzoate (944052-65-7) → (3S)-3-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one (944052-68-0)

Guidance literature:

With Li[AlH₂(OCH₃)2]; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1002/jhet.5570440312

upstream raw materials:

(3S)-3-[(2R)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one

benzoic acid

Downstream raw materials:

(3S)-3-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]-2,3-dihydro-1H-isoindol-1-one