1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one

Base Information

• Chemical Name: 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one
• CAS No.: 1448820-19-6
• Molecular Formula: C₂₂H₂₅N₃O₂
• Molecular Weight: 363.459
• Mol file: 1448820-19-6.mol

Synonyms:1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one

Chemical Property of 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one

There total 3 articles about 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

L-(+)-isoleucine hydrazide (163979-02-0) + triethoxymethylbenzene (1663-61-2) → 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one (1448820-19-6)

Guidance literature:

With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; for 2h; Reflux;

DOI:10.1016/j.tetlet.2013.06.052

Reference yield:

methyl L-isoleucinate hydrochloride (18598-74-8) → 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one (1448820-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 24 h / 20 °C

2: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.tetlet.2013.06.052

Reference yield:

L-isoleucine (73-32-5,959215-79-3,18875-42-8) → 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(sec-butyl)imidazol-5(4H)-one (1448820-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 6 h / 0 °C

2: hydrazine hydrate / methanol / 24 h / 20 °C

3: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; hydrazine hydrate; In methanol; 5,5-dimethyl-1,3-cyclohexadiene;

DOI:10.1016/j.tetlet.2013.06.052

upstream raw materials:

methyl L-isoleucinate hydrochloride

L-isoleucine

L-(+)-isoleucine hydrazide

triethoxymethylbenzene