6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

Base Information

Chemical Name:6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid
CAS No.:900176-97-8
Molecular Formula:C₂₄H₂₁ClFN₃O₅
Molecular Weight:485.899
Hs Code.:

Synonyms:6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

Suppliers and Price of 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

There total 1 articles about 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 617703-01-2
N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 900176-97-8
6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

Guidance literature:: N-(2-(tert-butoxycarbonylamino)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid; With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 70 - 85 ℃; for 34h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 900176-97-8
6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid

: C₂₄H₂₃ClFN₃O₄

Guidance literature:: 6-{4-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]phenyl}-2-chloro-5-fluoronicotinic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

With sodium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 2h;