2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

Base Information

Chemical Name:2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate
CAS No.:342624-57-1
Molecular Formula:C₂₃H₂₃Cl₃O₆
Molecular Weight:501.791
Hs Code.:

Synonyms:2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

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Chemical Property of 2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

Chemical Property:

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Technology Process of 2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

There total 8 articles about 2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 143726-85-6
4-hydroxymethylbenzoic acid tert-butyl ester

: 342624-15-1
2,2,2-trichloroethyl-(3-carboxyphenyl)acetate

: 342624-57-1
2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm000145g

Reference yield:

: 121-91-5
isophthalic acid

: 342624-57-1
2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: Et₃N / methanol; H₂O

1.2: 49 percent / dimethylformamide / 2 h / 100 °C

2.1: oxalyl chloride / DMF / CH₂Cl₂ / 1 h / 20 °C

3.1: diethyl ether; benzene / 0.5 h / cooling

4.1: 68 percent / Ag₂O / 0.5 h / 50 - 60 °C

5.1: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

6.1: 67 percent / DMAP; dicyclohexylcarbodiimide / tetrahydrofuran

With dmap; oxalyl dichloride; hydrogen; triethylamine; dicyclohexyl-carbodiimide; silver(l) oxide; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene; 4.1: Arndt-Eistert homologation;
DOI:10.1021/jm000145g

Reference yield:

: 67852-96-4
3-(benzyloxycarbonyl)benzoyl chloride

: 342624-57-1
2,2,2-trichloroethyl-{3-[4'-(tert-butyloxycarbonyl)benzyloxycarbonyl]phenyl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; benzene / 0.5 h / cooling

2: 68 percent / Ag₂O / 0.5 h / 50 - 60 °C

3: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

4: 67 percent / DMAP; dicyclohexylcarbodiimide / tetrahydrofuran

With dmap; hydrogen; dicyclohexyl-carbodiimide; silver(l) oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; benzene; 2: Arndt-Eistert homologation;
DOI:10.1021/jm000145g