5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine
• CAS No.: 111452-86-9
• Molecular Formula: C₂₇H₂₈N₆O₆S
• Molecular Weight: 564.622
• Mol file: 111452-86-9.mol

Synonyms:5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

Chemical Property of 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

There total 4 articles about 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2,4-diamino-5-(3-hydroxy-4-methoxybenzyl)-pyrimidine (83166-76-1) + 4--4'-nitrodiphenylsulphone (111453-08-8) → 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-86-9)

Guidance literature:

With sodium methylate; In 2-methoxy-ethanol; Ambient temperature;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4'-nitro-4-N-tosylaminodiphenyl sulfide (111453-03-3) → 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-86-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / CuI, aq. KOH / ethanol / 2 h / Heating

2: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

3: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

4: 61 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

With potassium hydroxide; copper(l) iodide; sulfuric acid; dihydrogen peroxide; sodium methylate; acetic acid; In ethanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4--4'-nitrodiphenylsulphide (111453-06-6) → 5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-86-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

2: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

3: 61 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

With sulfuric acid; dihydrogen peroxide; sodium methylate; acetic acid; In 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

upstream raw materials:

2,4-diamino-5-(3-hydroxy-4-methoxybenzyl)-pyrimidine

4--4'-nitrodiphenylsulphone

4'-nitro-4-N-tosylaminodiphenyl sulfide

4--4'-nitrodiphenylsulphide

Downstream raw materials:

5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine