5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

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Chemical Name:5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine
CAS No.:128076-26-6
Molecular Formula:C₂₇H₃₀N₆O₄S
Molecular Weight:534.639
Hs Code.:

Synonyms:5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

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Chemical Property of 5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

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Technology Process of 5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

There total 6 articles about 5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 111452-86-9
5-(4-Methoxy-3-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

: 128076-26-6
5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: With hydrogen; Raney Ni (W₂); In methanol; 2-methoxy-ethanol; at 50 ℃; for 1.33333h; under 3750.3 Torr;
DOI:10.1016/0223-5234(92)90007-N

Reference yield:

: 111453-03-3
4'-nitro-4-N-tosylaminodiphenyl sulfide

: 128076-26-6
5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / CuI, aq. KOH / ethanol / 2 h / Heating

2: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

3: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

4: 61 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

5: 95 percent / H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With potassium hydroxide; copper(l) iodide; sulfuric acid; hydrogen; dihydrogen peroxide; sodium methylate; acetic acid; Raney Ni (W₂); In methanol; ethanol; 2-methoxy-ethanol;
DOI:10.1016/0223-5234(92)90007-N

Reference yield:

: 83166-76-1
2,4-diamino-5-(3-hydroxy-4-methoxybenzyl)-pyrimidine

: 128076-26-6
5-(3-{3-[4-(4-Amino-benzenesulfonyl)-phenylamino]-propoxy}-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / NaOMe / 2-methoxy-ethanol / Ambient temperature

2: 95 percent / H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With hydrogen; sodium methylate; Raney Ni (W₂); In methanol; 2-methoxy-ethanol;
DOI:10.1016/0223-5234(92)90007-N