ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate

Base Information

• Chemical Name: ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate
• CAS No.: 1244044-90-3
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Mol file: 1244044-90-3.mol

Synonyms:ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate

Chemical Property of ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate

There total 1 articles about ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + N-cyclohexyl-4-formylbenzamide (128204-86-4) → ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate (1244044-90-3)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With triethylamine; lithium bromide; In acetonitrile; at 20 ℃; for 0.0833333h; Inert atmosphere;

N-cyclohexyl-4-formylbenzamide; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja105194s

Reference yield: 96.0%

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate (1244044-90-3) → (E)-ethyl 3-{4-[(E)-(cyclohexylimino)methyl]phenyl}acrylate (1244044-97-0)

Guidance literature:

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With triethylsilane; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; chemoselective reaction;

DOI:10.1021/ja105194s

Reference yield: 96.0%

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate (1244044-90-3) → ethyl 4-formylcinnamate (51828-89-8,92636-27-6,92636-26-5)

Guidance literature:

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With triethylsilane; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

With citric acid; In tetrahydrofuran; dichloromethane; water; at 45 ℃; for 2h; chemoselective reaction;

DOI:10.1021/ja105194s

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

N-cyclohexyl-4-formylbenzamide

Downstream raw materials:

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]phenyl}acrylate

(E)-ethyl 3-{4-[(E)-(cyclohexylimino)methyl]phenyl}acrylate

ethyl 4-formylcinnamate