3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• CAS No.: 51828-89-8
• Molecular Formula: C12H12O3
• Molecular Weight: 204.225
• Mol file: 51828-89-8.mol

Synonyms:3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER;4-FORMYLCINNAMIC ACID ETHYL ESTER;ETHYL 4-FORMYLCINNAMATE

Chemical Property of 3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 5.7E-05mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 346.6°Cat760mmHg
• Flash Point: 153.9°C
• PSA: 43.37000
• Density: 1.143g/cm³
• LogP: 2.07540

Purity/Quality:

98%Min ^*data from raw suppliers

(E)-Ethyl3-(4-formylphenyl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER

There total 27 articles about 3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-benzaldehyde (1122-91-4) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3‐(4‐formylphenyl)acrylate (51828-89-8)

Guidance literature:

With C₂₆H₁₆Cl₂F₄N₄Pd; sodium carbonate; In N,N-dimethyl acetamide; at 140 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1177/1747519820917883

Reference yield: 96.0%

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate (1244044-90-3) → ethyl 4-formylcinnamate (51828-89-8,92636-27-6,92636-26-5)

Guidance literature:

ethyl (2E)-3-{[(cyclohexylamino)carbonyl]}phenylacrylate; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With triethylsilane; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

With citric acid; In tetrahydrofuran; dichloromethane; water; at 45 ℃; for 2h; chemoselective reaction;

DOI:10.1021/ja105194s

Reference yield: 93.0%

4-bromo-benzaldehyde (1122-91-4) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 4-formylcinnamate (51828-89-8,92636-27-6,92636-26-5)

Guidance literature:

With potassium phosphate; In water; at 100 ℃; for 10h; Green chemistry;

DOI:10.1016/j.jorganchem.2019.06.029

upstream raw materials:

ethanol

4-formylcinnamic acid

4-chlorobenzaldehyde

ethyl acrylate

Downstream raw materials:

C₂₃H₂₃NO₅

C₂₃H₂₃NO₅

tert-butyl-(4-(3-(4-(3-(2-aminophenylamino)-3-oxoprop-1-enyl)phenyl)acryloyl)phenyl)carbamate

tert-butyl-(3-(3-(4-(3-(2-aminophenylamino)-3-oxoprop-1-enyl)phenyl)acryloyl)phenyl)carbamate