2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol

Base Information

• Chemical Name: 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol
• CAS No.: 1558753-99-3
• Molecular Formula: C₁₃H₁₈Cl₂O₂
• Molecular Weight: 277.191
• Mol file: 1558753-99-3.mol

Synonyms:2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol

Chemical Property of 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol

There total 5 articles about 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutanoate (1558753-97-1) → 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol (1558753-99-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja411772n

Reference yield:

3,3-dimethyl-butan-2-one (75-97-8) → 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol (1558753-99-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide; potassium permanganate / water / 16.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

1.2: Cooling; Inert atmosphere; Schlenk technique

2.1: sodium hydroxide; sodium tetrahydroborate / water / 16.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.2: Inert atmosphere; Schlenk technique

3.1: acetyl chloride / 4 h / 65 °C / Inert atmosphere; Schlenk technique

4.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere; Schlenk technique

4.2: 13 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

5.1: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With sodium tetrahydroborate; potassium permanganate; lithium aluminium tetrahydride; sodium hydride; acetyl chloride; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja411772n

Reference yield:

trimethylpyruvic acid (815-17-8) → 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutan-1-ol (1558753-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide; sodium tetrahydroborate / water / 16.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

1.2: Inert atmosphere; Schlenk technique

2.1: acetyl chloride / 4 h / 65 °C / Inert atmosphere; Schlenk technique

3.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 13 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

4.1: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; acetyl chloride; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja411772n

upstream raw materials:

methyl 2-[(2,6-dichlorobenzyl)oxy]-3,3-dimethylbutanoate

3,3-dimethyl-butan-2-one

trimethylpyruvic acid

2-hydroxy-3,3-dimethylbutanoic acid