5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

Base Information

Chemical Name:5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid
CAS No.:1312697-82-7
Molecular Formula:C₁₉H₁₁Cl₂F₃N₂O₃
Molecular Weight:443.209
Hs Code.:

Synonyms:5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

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Chemical Property of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

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Technology Process of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

There total 17 articles about 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1437053-52-5
methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

: 1312697-82-7
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1312697-82-7
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran / 4 h / 70 °C / Sealed tube

2: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 2 h / 20 - 68 °C

3: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; caesium carbonate; sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 1437053-40-1
5-(hydroxymethyl)indolizin-8-yl trifluoromethanesulfonate

: 1312697-82-7
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; carbon dioxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 2 h / 50 °C / 2585.81 Torr

2: manganese(IV) oxide / dichloromethane / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 2 h / 20 °C

4: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 2 h / 20 - 68 °C

5: sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

With manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; carbon dioxide; hydroxylamine hydrochloride; sodium acetate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;