methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

Base Information

Chemical Name:methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate
CAS No.:1437053-52-5
Molecular Formula:C₂₀H₁₃Cl₂F₃N₂O₃
Molecular Weight:457.236
Hs Code.:

Synonyms:methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

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Chemical Property of methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

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Technology Process of methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

There total 14 articles about methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1437053-49-0
(E)-methyl 5-((hydroxyimino)methyl)indolizine-8-carboxylate

: 1437053-52-5
methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

Guidance literature:: With [bis(acetoxy)iodo]benzene; In tetrahydrofuran; at 68 ℃; for 2h;
DOI:10.1016/j.tetlet.2014.02.003

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1437053-52-5
methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran / 4 h / 70 °C / Sealed tube

2: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 2 h / 20 - 68 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; caesium carbonate; In tetrahydrofuran;

Reference yield:

: 1437053-40-1
5-(hydroxymethyl)indolizin-8-yl trifluoromethanesulfonate

: 1437053-52-5
methyl 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)indolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; carbon dioxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / methanol / 2 h / 50 °C / 2585.81 Torr

2: manganese(IV) oxide / dichloromethane / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 2 h / 20 °C

4: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 2 h / 20 - 68 °C

With manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [bis(acetoxy)iodo]benzene; carbon dioxide; hydroxylamine hydrochloride; sodium acetate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;