acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester

Base Information

• Chemical Name: acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester
• CAS No.: 354578-84-0
• Molecular Formula: C₁₈H₃₄O₃Si
• Molecular Weight: 326.552
• Mol file: 354578-84-0.mol

Synonyms:acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester

Chemical Property of acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester

There total 3 articles about acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

triisopropylsilyl chloride (13154-24-0) + (6-hydroxycyclohex-1-en-1-yl)methyl acetate (354578-83-9) → acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester (354578-84-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1246/cl.2001.546

Reference yield:

2-(hydroxymethyl)cyclohex-2-en-1-one (105956-40-9) → acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester (354578-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2: 85 percent / CeCl₃*H₂O; NaBH₄ / methanol / 0.33 h / 20 °C

3: 86 percent / imidazole / dimethylformamide / 48 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; 2: Luche reduction;

DOI:10.1246/cl.2001.546

Reference yield:

(6-oxocyclohex-1-en-1-yl)methyl acetate (106281-44-1) → acetic acid 6-triisopropylsilanyloxy-cyclohex-1-enylmethyl ester (354578-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / CeCl₃*H₂O; NaBH₄ / methanol / 0.33 h / 20 °C

2: 86 percent / imidazole / dimethylformamide / 48 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; In methanol; N,N-dimethyl-formamide; 1: Luche reduction;

DOI:10.1246/cl.2001.546

upstream raw materials:

triisopropylsilyl chloride

(6-hydroxycyclohex-1-en-1-yl)methyl acetate

2-(hydroxymethyl)cyclohex-2-en-1-one

(6-oxocyclohex-1-en-1-yl)methyl acetate