8-Fluoroquinolin-5-amine

Base Information

Chemical Name:8-Fluoroquinolin-5-amine
CAS No.:175229-87-5
Molecular Formula:C9H7FN2
Molecular Weight:162.166
Hs Code.:2933499090
European Community (EC) Number:800-481-4
DSSTox Substance ID:DTXSID00588156
Wikidata:Q72437461
Mol file:175229-87-5.mol

Synonyms:8-Fluoroquinolin-5-amine;175229-87-5;5-AMINO-8-FLUOROQUINOLINE;5-quinolinamine,8-fluoro-(9ci);5-Quinolinamine, 8-fluoro-;MFCD09042730;SCHEMBL3027362;DTXSID00588156;VALHPDKWQSAKAA-UHFFFAOYSA-N;AKOS000126771;SB67787;BS-21757;SY271584;DB-065060;CS-0120636;E75999;EN300-399117

Suppliers and Price of 8-Fluoroquinolin-5-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Amino-8-fluoroquinoline
50mg
$ 80.00

TRC
5-Amino-8-fluoroquinoline
250mg
$ 325.00

SynQuest Laboratories
5-Amino-8-fluoroquinoline 98%
250 mg
$ 208.00

SynQuest Laboratories
5-Amino-8-fluoroquinoline 98%
1 g
$ 480.00

Crysdot
8-Fluoroquinolin-5-amine 95+%
5g
$ 677.00

Chemenu
8-Fluoroquinolin-5-amine 95%
5g
$ 640.00

Apolloscientific
5-Amino-8-fluoroquinoline 98%
250mg
$ 189.00

Apolloscientific
5-Amino-8-fluoroquinoline 98%
1g
$ 435.00

American Custom Chemicals Corporation
5-AMINO-8-FLUOROQUINOLINE 95.00%
5MG
$ 501.77

Alichem
8-Fluoroquinolin-5-amine
25g
$ 2030.10

Total 18 raw suppliers

Chemical Property of 8-Fluoroquinolin-5-amine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.677
Boiling Point:326.306 ºC at 760 mmHg
Flash Point:151.145 ºC
PSA：38.91000
Density:1.316 g/cm³
LogP:2.53730
Storage Temp.:2-8°C(protect from light)
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:162.05932639
Heavy Atom Count:12
Complexity:163

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-8-fluoroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=CC(=C2N=C1)F)N
Uses 5-Amino-8-fluoroquinoline is an intermediate for organic synthesis. It functions as a reagent in the preparation of pyridoquinolinones and pyridoquinolinecarboxylates as bactericides.

Technology Process of 8-Fluoroquinolin-5-amine

There total 3 articles about 8-Fluoroquinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 94832-39-0
8-fluoro-5-nitroquinoline

: 175229-87-5
5-amino-8-fluoroquinoline

Guidance literature:: With hydrogen; palladium on activated charcoal; In benzene;
DOI:10.1248/bpb.20.646

Reference yield:

: 394-68-3
8-fluoroquinoline

: 175229-87-5
5-amino-8-fluoroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / 61 percent HNO₃; H₂SO₄ / 1 h / 20 °C

2: 65 percent / H₂ / 5 percent Pd/C / benzene

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In benzene; 1: Nitration / 2: Reduction;
DOI:10.1248/bpb.20.646

Reference yield:

: 348-54-9
2-Fluoroaniline

: 175229-87-5
5-amino-8-fluoroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium m-nitrobenzenesulfonate; 80 percent H₂SO₄ / 4 h / 140 °C

2: 60 percent / 61 percent HNO₃; H₂SO₄ / 1 h / 20 °C

3: 65 percent / H₂ / 5 percent Pd/C / benzene

With sulfuric acid; hydrogen; nitric acid; sodium 3-nitrobenzenesulfonate; palladium on activated charcoal; In benzene; 1: Skraup reaction / 2: Nitration / 3: Reduction;
DOI:10.1248/bpb.20.646