2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

Base Information

• Chemical Name: 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether
• CAS No.: 126266-12-4
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.312
• Mol file: 126266-12-4.mol

Synonyms:2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

Chemical Property of 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

There total 7 articles about 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-Formylpiperidine (2591-86-8) + 2-(2-iodo-4,5-(methylenedioxy)phenyl)ethyl benzyl ether (183114-92-3) → 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether (126266-12-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 9h;

DOI:10.1021/jo961179s

Reference yield: 76.0%

5-(2-benzyloxyethyl)-6-bromo-1,3-benzodioxole + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether (126266-12-4)

Guidance literature:

5-(2-benzyloxyethyl)-6-bromo-1,3-benzodioxole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2013.08.012

Reference yield:

2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanol (52199-45-8) → 2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether (126266-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 86.8percent KOH / dimethylsulfoxide / 4 h / 25 °C

2: 87 percent / n-BuLi / tetrahydrofuran; hexane / 9 h / -78 °C

With potassium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; dimethyl sulfoxide;

DOI:10.1021/jo961179s

upstream raw materials:

N-Formylpiperidine

2-(2-iodo-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanol

3,4-methylenedioxyphenethyl alcohol

Downstream raw materials:

2-[6-(2-Benzyloxy-ethyl)-benzo[1,3]dioxol-5-yl]-3-hydroxy-cyclopent-2-enone

2-[6-(2-Benzyloxy-ethyl)-benzo[1,3]dioxol-5-yl]-cyclopentane-1,3-dione

3-chloro-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one

3-<2-<(trimethylsilyl)methyl-2-propenyl>amino>-2-<2'-(2-(benzyloxy)ethyl)-4',5'-(methylenedioxy)phenyl>-2-cyclopenten-1-one