tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

Base Information

Chemical Name:tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate
CAS No.:1283526-63-5
Molecular Formula:C₁₈H₂₅F₃N₂O₅
Molecular Weight:406.402
Hs Code.:

Synonyms:tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

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Chemical Property of tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

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Technology Process of tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

There total 3 articles about tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1283526-57-7
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol

: 1283526-63-5
tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

Guidance literature:: 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol; With dmap; sulfuric acid; triethylamine; In acetonitrile; for 2h; Reflux;

With sodium hydrogencarbonate; In water; pH=8;

di-tert-butyl dicarbonate; With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 99758-66-4
5-(tert-butyl)-2-methoxy-3-nitrobenzaldehyde

: 1283526-63-5
tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

1.2: 2 h / 20 °C

2.1: dmap; triethylamine; sulfuric acid / acetonitrile / 2 h / Reflux

2.2: pH 8

2.3: 4 h / 20 °C

With dmap; sulfuric acid; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; acetonitrile;

Reference yield:

: 2725-53-3
2-hydroxy-5-t-butylbenzaldehyde

: 1283526-63-5
tert-butyl 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitronium tetrafluoborate / acetonitrile / 1 h / -40 - -20 °C

1.2: 15 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2.2: 2 h / 20 °C

3.1: dmap; triethylamine; sulfuric acid / acetonitrile / 2 h / Reflux

3.2: pH 8

3.3: 4 h / 20 °C

With dmap; nitronium tetrafluoborate; sulfuric acid; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; acetonitrile;