N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid

Base Information

• Chemical Name: N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid
• CAS No.: 81659-76-9
• Molecular Formula: C₁₅H₁₇Cl₃N₂O₇
• Molecular Weight: 443.668

Synonyms:N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid

Chemical Property of N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid

Chemical Property:

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Technology Process of N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid

There total 3 articles about N³-(p-methoxybenzyloxycarbonyl)-N²-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone (81659-74-7) → N3-(p-methoxybenzyloxycarbonyl)-N2-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid (81659-76-9)

Guidance literature:

With sodium hydroxide; In water; acetone; at 0 - 5 ℃; for 2h;

DOI:10.1246/bcsj.55.633

Reference yield:

(S)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxo-4-oxazolidineacetic acid (81659-73-6) → N3-(p-methoxybenzyloxycarbonyl)-N2-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid (81659-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1: diphenyl diphosphorazidate, Et₃N / benzene / 15 h

2: benzene / 3 h / Heating

3: 98 percent / NaOH / acetone; H₂O / 2 h / 0 - 5 °C

With sodium hydroxide; diphenyl diphosphorazidate; triethylamine; In water; acetone; benzene;

DOI:10.1246/bcsj.55.633

Reference yield:

(S)-4-Azidocarbonylmethyl-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester → N3-(p-methoxybenzyloxycarbonyl)-N2-(2,2,2-trichloroethoxycarbonyl)-L-2,3-diaminopropanoic acid (81659-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 3 h / Heating

2: 98 percent / NaOH / acetone; H₂O / 2 h / 0 - 5 °C

With sodium hydroxide; In water; acetone; benzene;

DOI:10.1246/bcsj.55.633

upstream raw materials:

(S)-4-(p-methoxybenzyloxycarbonylaminomethyl)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxazolidinone

(S)-3-(2,2,2-trichloroethoxycarbonyl)-5-oxo-4-oxazolidineacetic acid

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