(1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide

Base Information

• Chemical Name: (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide
• CAS No.: 1058662-15-9
• Molecular Formula: C₁₆H₂₂INO₂S
• Molecular Weight: 419.327
• Mol file: 1058662-15-9.mol

Synonyms:(1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide

Chemical Property of (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide

There total 1 articles about (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(1R,2R,3R,5S)-(-)-Isopinocampheylamine (69460-11-3) + p-Iodobenzenesulfonyl chloride (98-61-3) → (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide (1058662-15-9)

Guidance literature:

With pyridine; In dichloromethane; Inert atmosphere;

DOI:10.1021/ol8012809 DOI:10.1039/b821892g

Reference yield: 76.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + (1'R,2'R,3'R,5'S)-4-iodo-N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)phenylsulfonamide (1058662-15-9) → (1'R,2'R,3'R,5'S)-(E)-tert-butyl 3-(4-(N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)sulfonamido)phenyl)acrylate (1058661-83-8)

Guidance literature:

With C₃₁H₃₈ClN₃Pd; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol8012809

upstream raw materials:

(1R,2R,3R,5S)-(-)-Isopinocampheylamine

p-Iodobenzenesulfonyl chloride

Downstream raw materials:

(1'R,2'R,3'R,5'S)-(E)-tert-butyl 3-(4-(N-(2',6',6'-trimethyl-bicyclo[3.1.1]hept-3'-yl)sulfonamido)phenyl)acrylate