ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

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Chemical Name:ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate
CAS No.:1262394-33-1
Molecular Formula:C₃₁H₄₀N₂O₄
Molecular Weight:504.67
Hs Code.:

Synonyms:ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

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Chemical Property of ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

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Technology Process of ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

There total 12 articles about ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 660449-17-2
ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]prop-2-enoate

: 1262394-33-1
ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm101236h

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 1262394-33-1
ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

2.1: methanesulfonic acid / toluene / 17 h / Reflux

3.1: palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / tert-butyl alcohol / 15 h / 70 °C / Inert atmosphere

4.1: trifluoroacetic acid / tetrahydrofuran / 4 h / 20 °C

5.1: ammonia; hydrogen / tetrahydrofuran; methanol / 8 h / 70 °C / 3750.38 Torr

6.1: tetrahydrofuran / 3 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

7.2: 0.5 h / 20 °C

8.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; methanesulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; palladium diacetate; sodium hydride; 2,2'-bis(diphenylphosphino)biphenyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol; 8.1: Heck reaction;
DOI:10.1021/jm101236h

Reference yield:

: C₂₁H₂₄N₂O

: 1262394-33-1
ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 70 °C

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil; 3.1: Heck reaction;
DOI:10.1021/jm101236h