6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

Base Information

Chemical Name:6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester
CAS No.:1421503-69-6
Molecular Formula:C₂₃H₂₃F₄N₃O₃
Molecular Weight:465.448
Hs Code.:

Synonyms:6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

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Chemical Property of 6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

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Technology Process of 6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

There total 8 articles about 6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1421503-68-5
6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile

: 124-41-4
sodium methylate

: 1421503-69-6
6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

Guidance literature:: With methanol; at 20 ℃; for 18h;

Reference yield:

: 1421503-36-7
6-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carbaldehyde

: 1421503-69-6
6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; hydroxylamine hydrochloride / acetonitrile / 3 h / 60 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3.1: methanol / 18 h / 20 °C

With methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; triethylamine; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1421503-65-2
(2-bromo-4-fluoro-5-methoxy-phenyl)methanol

: 1421503-69-6
6-[5-fluoro-4-methoxy-2-(2,2,2-trifluoro-ethyl)-phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus tribromide / dichloromethane / 18 h / 0 - 20 °C

2: copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

5: methanol / 18 h / 20 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; phosphorus tribromide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;