ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

Base Information

Chemical Name:ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate
CAS No.:1093379-21-5
Molecular Formula:C₂₁H₂₅NO₃S
Molecular Weight:371.5
Hs Code.:

Synonyms:ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

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Chemical Property of ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

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Technology Process of ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

There total 6 articles about ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 64-17-5
ethanol

: 1093378-96-1
1-benzyl-6',7'-dihydrospiro[piperidine-4,44'-thieno[3,2-c]pyran]-6'-carbonitrile

: 1093379-21-5
ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

Guidance literature:: With sulfuric acid; In water; for 18h; Reflux;
DOI:10.1021/jm300302p

Reference yield:

: 1070709-12-4
1-benzyl-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

: 1093379-21-5
ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / -20 - 0 °C

2: sulfuric acid / water / 18 h / Reflux

With sulfuric acid; boron trifluoride diethyl etherate; In dichloromethane; water;
DOI:10.1021/jm300302p

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1093379-21-5
ethyl 1-benzyl-6',7'-dihyrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 - 0.3 h / -84 °C

1.2: 3 h / -84 - 20 °C

2.1: toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 24 h / 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 1.5 h / -20 - 0 °C

4.1: sulfuric acid / water / 18 h / Heating / reflux

4.2: 0 °C / pH 7 - 8

With n-butyllithium; sulfuric acid; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; trimethyl orthoformate; water; In tetrahydrofuran; methanol; hexane; dichloromethane;