4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

Base Information

Chemical Name:4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine
CAS No.:1380672-05-8
Molecular Formula:C₂₂H₁₅ClN₈O₂
Molecular Weight:458.866
Hs Code.:

Synonyms:4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

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Chemical Property of 4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

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Technology Process of 4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

There total 4 articles about 4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312919-50-8
N''-(2-chlorophenyl)pyrimidine-4-carboximidhydrazide

: 1380672-63-8
(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

: 1380672-05-8
4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

Guidance literature:: (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid; With trichlorophosphate; In toluene; for 2h; Reflux;

N''-(2-chlorophenyl)pyrimidine-4-carboximidhydrazide; In dichloromethane; at 20 ℃; for 5h; Reflux;

Reference yield:

: 31462-59-6
pyrimidine-4-carboxylic acid

: 1380672-05-8
4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane / 18 h / 20 °C

1.2: 16 h / 20 °C

2.1: phosphorus pentachloride / toluene / 3 h / Reflux

2.2: 2 h / 20 °C

3.1: trichlorophosphate / toluene / 2 h / Reflux

3.2: 5 h / 20 °C / Reflux

With thionyl chloride; phosphorus pentachloride; trichlorophosphate; In dichloromethane; toluene;

Reference yield:

: 19353-97-0
2-methoxy-isonicotinic acid hydrazide

: 1380672-05-8
4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: trichlorophosphate / toluene / 2 h / Reflux

2.2: 5 h / 20 °C / Reflux

With trichlorophosphate; In tetrahydrofuran; toluene;