2-methoxyisonicotinohydrazide

Base Information

• Chemical Name: 2-methoxyisonicotinohydrazide
• CAS No.: 19353-97-0
• Molecular Formula: C7H9 N3 O2
• Molecular Weight: 167.167
• Hs Code.: 2933399090
• Mol file: 19353-97-0.mol

Synonyms:Isonicotinicacid, 2-methoxy-, hydrazide (7CI,8CI); 2-Methoxyisonicotinic acid hydrazide;NSC 280611

Chemical Property of 2-methoxyisonicotinohydrazide

Chemical Property:

• Melting Point: 135-137°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 77.24000
• Density: 1.245g/cm³
• LogP: 0.78490
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxyisonicotinohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methoxyisonicotinohydrazide

There total 7 articles about 2-methoxyisonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-methoxy-isonicotinic acid (105596-63-2) → 2-methoxy-isonicotinic acid hydrazide (19353-97-0)

Guidance literature:

2-methoxy-isonicotinic acid; With thionyl chloride; In methanol; at 20 ℃; for 2h; Reflux;

With hydrazine hydrate; In tetrahydrofuran; for 0.5h; Product distribution / selectivity; Reflux;

Reference yield: 80.0%

methyl 2-methoxyisonicotinate (26156-51-4) → 2-methoxy-isonicotinic acid hydrazide (19353-97-0)

Guidance literature:

With hydrazine; In ethanol; at 75 ℃; for 12h;

Reference yield:

2-chloro-6-methoxyisonicotinic acid methyl ester (42521-10-8) → 2-methoxy-isonicotinic acid hydrazide (19353-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; aqueous methanol; potassium acetate / Hydrogenation

2: ethanol; N₂H₄+H₂O

With methanol; palladium on activated charcoal; ethanol; potassium acetate; hydrazine hydrate;

DOI:10.1002/hlca.19550380425

upstream raw materials:

methyl 2-methoxyisonicotinate

methyl 2-chloroisonicotinate

methyl 2,6-dichloroisonicotinate

2-chloro-6-methoxyisonicotinic acid methyl ester

Downstream raw materials:

4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

2-benzyloxy-4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

4-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)pyrimidine

4-(5-((E)-2-(5-(2,4-dichlorophenyl)-4-(2-chlorophenyl)-4H-1,2,4-triazo-1-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine

Refernces

• 1、 -. "TRIAZOLE DERIVATIVES AS WNT SIGNALING PATHWAY INHIBITORS". Page/Page column 45. . Retrieved 2012/06/30.
• 2、 -. "MGLUR5 MODULATORS". Page/Page column 59. . Retrieved 2008/06/13.