Technology Process of N-{3-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)benzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide
There total 7 articles about N-{3-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)benzoyl]-1H-pyrrolo[2,3-c]pyridin-7-yl}cyclopropanecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,5-dimethylisoxazole-4-boronic acid; N-[3-(4-bromo-2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-7-yl]cyclopropanecarboxamide;
With
water; potassium carbonate;
In
1,4-dioxane;
for 0.0833333h;
Inert atmosphere;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane;
at 90 ℃;
for 4h;
Sealed vial;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid / sulfuric acid / 1 h / 20 - 55 °C
2.1: hydrogenchloride; tin(ll) chloride / water / 1 h / 60 °C
2.2: pH 1 - 2
3.1: N-Bromosuccinimide / acetonitrile / 0.75 h / 90 °C
4.1: hydrogenchloride; sodium nitrite / water / 2 h / -10 - -5 °C
4.2: 4 h / -10 - -5 °C
5.1: thionyl chloride / dichloromethane / 5 h / Reflux
6.1: aluminum (III) chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
7.1: potassium carbonate; water / 1,4-dioxane / 0.08 h / Inert atmosphere
7.2: 4 h / 90 °C / Sealed vial
With
hydrogenchloride; N-Bromosuccinimide; thionyl chloride; water; nitric acid; potassium carbonate; tin(ll) chloride; sodium nitrite;
aluminum (III) chloride; sulfuric acid;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / dichloromethane / 5 h / Reflux
2.1: aluminum (III) chloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
3.1: potassium carbonate; water / 1,4-dioxane / 0.08 h / Inert atmosphere
3.2: 4 h / 90 °C / Sealed vial
With
thionyl chloride; water; potassium carbonate;
aluminum (III) chloride;
In
1,4-dioxane; dichloromethane;
