N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite

Base Information

• Chemical Name: N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite
• CAS No.: 149624-88-4
• Molecular Formula: C₃₉H₅₀N₅O₃P
• Molecular Weight: 667.831

Synonyms:N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite

Chemical Property of N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite

There total 5 articles about N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + N6-<<1-(triphenylmethyl)imidazol-4-yl>acetyl>-6-amino-1-hexanol (149624-86-2) → N6-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite (149624-88-4)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1021/jo00069a022

Reference yield:

trityl chloride (76-83-5) → N6-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite (149624-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / pyridine / 48 h / Ambient temperature

2: pyridine, DCC / tetrahydrofuran / 24 h / Ambient temperature

3: tetrahydrofuran / 0.5 h / Ambient temperature

4: 89 percent / tetrazole / acetonitrile / 0.5 h / Ambient temperature

With pyridine; 1H-tetrazole; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo00069a022

Reference yield:

imidazole-4-acetic acid sodium salt → N6-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite (149624-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / pyridine / 48 h / Ambient temperature

2: pyridine, DCC / tetrahydrofuran / 24 h / Ambient temperature

3: tetrahydrofuran / 0.5 h / Ambient temperature

4: 89 percent / tetrazole / acetonitrile / 0.5 h / Ambient temperature

With pyridine; 1H-tetrazole; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo00069a022

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

N⁶-<<1-(triphenylmethyl)imidazol-4-yl>acetyl>-6-amino-1-hexanol

trityl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 149624-88-4 N⁶-<<1-(Triphenylmethyl)imidazol-4-yl>acetyl>-6-aminohexyl-2-cyanoethyl N,N-diisopropylphosphoramidite

Send

Send

Metric Ton KG G Pound L ML

Send

Send