5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)-
CAS No.:330784-50-4
Molecular Formula:C₂₃H₂₇N₇O₃
Molecular Weight:449.512
Hs Code.:
Mol file:330784-50-4.mol

Synonyms:(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(4-methoxybenzylamino)-5-[N-(2-pyrimidylmethyl)-carbamoyl]pyrimidine

Suppliers and Price of 5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 5 raw suppliers

Chemical Property of 5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)-

Chemical Property:

Purity/Quality:: 95%+HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Deschloro Avanafil is an impurity of avanafil (A794670). Avanafil is a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.

Technology Process of 5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)-

There total 7 articles about 5-Pyrimidinecarboxamide, 2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-4-[[(4-methoxyphenyl)methyl]amino]-N-(2-pyrimidinylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 476449-27-1
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-phenylthio-5-[N-(2-pyrimidylmethyl)carbamoyl]pyrimidine

: 2393-23-9
4-methoxy-benzylamine

: 330784-50-4
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(4-methoxybenzylamino)-5-[N-(2-pyrimidylmethyl)-carbamoyl]pyrimidine

Guidance literature:: With triethylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform; water;

Reference yield:

: 53554-29-3
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

: 330784-50-4
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(4-methoxybenzylamino)-5-[N-(2-pyrimidylmethyl)-carbamoyl]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate

2: 20 °C

3: 3-chloro-benzenecarboperoxoic acid / 4 h / 0 - 10 °C

4: 4 h

5: sodium hydroxide / 12 h / 60 °C

6: N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; benzotriazol-1-ol / 8 h

With benzotriazol-1-ol; N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate;
DOI:10.1039/d2ra01224c

Reference yield:

: 211230-35-2
4-(4-methoxybenzylamino)-2-methanesulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 330784-50-4
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(4-methoxybenzylamino)-5-[N-(2-pyrimidylmethyl)-carbamoyl]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / 4 h / 0 - 10 °C

2: 4 h

3: sodium hydroxide / 12 h / 60 °C

4: N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; benzotriazol-1-ol / 8 h

With benzotriazol-1-ol; N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
DOI:10.1039/d2ra01224c